In NMR, the net magnetization is detected in the xy plane, giving rise to the FID (Free Induction Decay). The process by which the magnetization in the xy plane decays away, over time, to its equilibrium value of zero, is known as T2 relaxation, transversal relaxation, relaxation on the xy plane, or spin-spin relaxation.

In this blog post we show a simple experiment that teaches student how common over the counter (OTC) medications can be qualified and quantified for their different active pharmaceutical ingredients (API) using qNMR spectroscopy.

Nuclear Magnetic Resonance spectroscopy is based on the idea that some nuclei can behave as little magnetic bars (I spin number ≠ 0). In the presence of a magnetic field (B0) the nuclear spins feel a small torque for or against the B0 axis, which results in a net magnetization along the B0 direction. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada.

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Synthetic cannabinoids (SC) are designer drugs that aim to mimic the pharmacological effect of the natural cannabinoid (−)-trans-Δ9-tetrahydrocannabinol (THC). Many SCs have an even higher binding affinity to the CB1 receptor, which is responsible for the psychoactive effects…

As a class of complex cross-linked phenolic macromolecules, lignin is an important component of plant-based biomass.1 Biologically, lignin is a major component of lignocellulose, helping to strengthen cell walls in wood. A by-product of paper production…

…more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. Read More.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

…let’s look at regular eggs! Specifically, we’re going to look at cholesterol in the egg yolk. This idea hit me as I was taking my daily dose of raw eggs, when I thought, “why not try and analyze this to see what I am putting in my body?”.

Most NMR users know that phase correction is a very important adjustment that needs to be made to a spectrum. Practically speaking, the phase of a signal is related to the amount of signal observed above and below the baseline.