While low-field NMR has extremely favourable accessibility and affordable characteristics, the most common question that we get asked about our family of benchtop NMR spectrometers is with respect to any trade-offs that come from moving to lower-field.

The Limit of Detection (LoD) and Limit of Quantification (LoQ) are analytical benchmarks that define the practical boundaries for identifying and measuring a specific analyte within a given matrix, under particular experimental conditions.

Magnets used to manufacture low-field and high-field NMR spectrometers are not perfect and the magnetic field that they generate is prone to drift for a variety of reasons. However, during an NMR experiment it is important to keep the magnetic field as stable as possible to prevent the signals from drifting. This is taken care of by the lock system.

In this blog, we describe the T2-filter experiment, including its description and application.

It is common to mention the frequency of an NMR instrument instead of its field. When someone says: I have in my laboratory a 100 MHz instrument, it means that a spectrometer where the protons precess with a frequency of 100 MHz (Lamour frequency) is available in the lab…

In this blog, we discuss why gradient-based 2D NMR experiments enhance both efficiency and data quality and become the preferred choice for many applications. 

In this blog, we introduce our value-added software module, Experiment Designer. A powerful tool which allows advanced NMR users to code NMR pulse sequences through an intuitive graphical interface.

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Benchtop NMR is a great tool to assess the purity and identity of compounds, providing feedback on the success of the recrystallization of an organic compound.

It is well known that NMR analysis requires a higher concentration of analyte than any other spectroscopic method. For example, UV-Vis requires an analyte concentration range of only nM to µM, while NMR typically requires the analyte to be in the mM range (>1000 times more concentrated!). In this blog, we will demonstrate why NMR is considerably less sensitive than UV-Vis. We have chosen UV-Vis for this comparison as it is widely recognized as one of the most sensitive spectroscopic techniques.