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Category Academic Educational Industry News Feed NMR Topics 100 MHz NMR 11B NMR 129Xe NMR 13C NMR 19F NMR 19F NMR Spectroscopy 1H NMR 207Pb NMR 31P NMR 3H NMR APT Agrochemicals Applications Batteries Biochemistry Biopolymers Botanicals COSY CPMG Caffeine Content Cannabis Chemical Analysis Cosmetics DEPT Dithiazine Drug Analysis Drug Discovery Dyes Edible Oils Educational NMR Energy Enzyme Exchangeable Protons Exchangeable protons Flavor and Fragrances Flow NMR Fluorine-19 NMR Food Science Food and Beverage Forensics Forestry HETCOR HMBC HSQC Hands-on Learning Heteronuclear J-coupling Hydrogen sulfide Hydroxyl value Hyphenated NMR Illicit Drugs Year 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 >> Literature with Benchtop NMR Educational Alexander Köring 2024-11-26 Educational Alexander Köring 2024-11-26 How does the lock work? Magnets used to manufacture low-field and high-field NMR spectrometers are not perfect and the magnetic field that they generate is prone to drift for a variety of reasons. However, during an NMR experiment it is important to keep the magnetic field as stable as possible to prevent the signals from drifting. This is taken care of by the lock system. Read More Educational Thais Barbosa 2024-10-22 Educational Thais Barbosa 2024-10-22 Origin of Chemical Shifts It is common to mention the frequency of an NMR instrument instead of its field. When someone says: I have in my laboratory a 100 MHz instrument, it means that a spectrometer where the protons precess with a frequency of 100 MHz (Lamour frequency) is available in the lab… Read More Educational Susie Riegel 2024-09-24 Educational Susie Riegel 2024-09-24 DEPT: A tool for 13C peak assignments Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements. Read More Educational Thais Barbosa 2024-06-04 Educational Thais Barbosa 2024-06-04 Why does NMR have an inherently low sensitivity? It is well known that NMR analysis requires a higher concentration of analyte than any other spectroscopic method. For example, UV-Vis requires an analyte concentration range of only nM to µM, while NMR typically requires the analyte to be in the mM range (>1000 times more concentrated!). In this blog, we will demonstrate why NMR is considerably less sensitive than UV-Vis. We have chosen UV-Vis for this comparison as it is widely recognized as one of the most sensitive spectroscopic techniques. Read More Educational Alexander Köring 2024-05-27 Educational Alexander Köring 2024-05-27 What you should know about signal dispersion in benchtop NMR Do you know the difference between resolution and signal dispersion in NMR spectroscopy? Read our blog here. Read More Educational Godfrey Wills 2024-05-22 Educational Godfrey Wills 2024-05-22 Using NMR to observe the restricted rotation in amide bonds NMR is a great tool for the analysis of molecular properties such as the amide bond, which has a restricted rotation around the C–N bond. In Biochemistry, the amide bond is referred to as the peptide bond. This bond is formed by the union of a carboxyl group of one amino acid with the amino group of another amino acid. Read more. Read More Educational Juan Araneda 2024-03-16 Educational Juan Araneda 2024-03-16 What to expect: Chemical Shifts & Coupling Constants in Low-field NMR Spectroscopy One of the questions that we always get at tradeshows and conferences is how our instrument compares to high-field data. There are significant inherent differences between low-field and high-field instruments, but the most important from a chemistry point of view are sensitivity (S/N) and resonance dispersion (signal separation). Read More. Read More Educational Paul Hui 2023-10-05 Educational Paul Hui 2023-10-05 Beyond Structure Elucidation - Introduction to qNMR Part II - Calibrants In this blog post, I will talk about how to select a suitable calibrant as well as the difference between using an internal and external calibrant. When conducting qNMR experiments, one of the first things that needs to be considered is how the calibrant is employed to quantitate your sample. Read more. Read More Educational Alexander Köring 2023-10-02 Educational Alexander Köring 2023-10-02 Carbon-13 Satellites and Molecule Symmetry in Maleic Acid Symmetry is beauty. There are countless examples in nature, just think about honeycombs, flowers, starfish or….maleic acid! You probably can guess which of these examples will be the star in this blog post - no, sorry, it is not the starfish… Read More Educational Paul Hui 2023-09-12 Educational Paul Hui 2023-09-12 Beyond structural elucidation, introduction to qNMR – Part I Over the last few years, more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. Read more. 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Educational Alexander Köring 2024-11-26 Educational Alexander Köring 2024-11-26 How does the lock work? Magnets used to manufacture low-field and high-field NMR spectrometers are not perfect and the magnetic field that they generate is prone to drift for a variety of reasons. However, during an NMR experiment it is important to keep the magnetic field as stable as possible to prevent the signals from drifting. This is taken care of by the lock system. Read More
Educational Thais Barbosa 2024-10-22 Educational Thais Barbosa 2024-10-22 Origin of Chemical Shifts It is common to mention the frequency of an NMR instrument instead of its field. When someone says: I have in my laboratory a 100 MHz instrument, it means that a spectrometer where the protons precess with a frequency of 100 MHz (Lamour frequency) is available in the lab… Read More
Educational Susie Riegel 2024-09-24 Educational Susie Riegel 2024-09-24 DEPT: A tool for 13C peak assignments Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements. Read More
Educational Thais Barbosa 2024-06-04 Educational Thais Barbosa 2024-06-04 Why does NMR have an inherently low sensitivity? It is well known that NMR analysis requires a higher concentration of analyte than any other spectroscopic method. For example, UV-Vis requires an analyte concentration range of only nM to µM, while NMR typically requires the analyte to be in the mM range (>1000 times more concentrated!). In this blog, we will demonstrate why NMR is considerably less sensitive than UV-Vis. We have chosen UV-Vis for this comparison as it is widely recognized as one of the most sensitive spectroscopic techniques. Read More
Educational Alexander Köring 2024-05-27 Educational Alexander Köring 2024-05-27 What you should know about signal dispersion in benchtop NMR Do you know the difference between resolution and signal dispersion in NMR spectroscopy? Read our blog here. Read More
Educational Godfrey Wills 2024-05-22 Educational Godfrey Wills 2024-05-22 Using NMR to observe the restricted rotation in amide bonds NMR is a great tool for the analysis of molecular properties such as the amide bond, which has a restricted rotation around the C–N bond. In Biochemistry, the amide bond is referred to as the peptide bond. This bond is formed by the union of a carboxyl group of one amino acid with the amino group of another amino acid. Read more. Read More
Educational Juan Araneda 2024-03-16 Educational Juan Araneda 2024-03-16 What to expect: Chemical Shifts & Coupling Constants in Low-field NMR Spectroscopy One of the questions that we always get at tradeshows and conferences is how our instrument compares to high-field data. There are significant inherent differences between low-field and high-field instruments, but the most important from a chemistry point of view are sensitivity (S/N) and resonance dispersion (signal separation). Read More. Read More
Educational Paul Hui 2023-10-05 Educational Paul Hui 2023-10-05 Beyond Structure Elucidation - Introduction to qNMR Part II - Calibrants In this blog post, I will talk about how to select a suitable calibrant as well as the difference between using an internal and external calibrant. When conducting qNMR experiments, one of the first things that needs to be considered is how the calibrant is employed to quantitate your sample. Read more. Read More
Educational Alexander Köring 2023-10-02 Educational Alexander Köring 2023-10-02 Carbon-13 Satellites and Molecule Symmetry in Maleic Acid Symmetry is beauty. There are countless examples in nature, just think about honeycombs, flowers, starfish or….maleic acid! You probably can guess which of these examples will be the star in this blog post - no, sorry, it is not the starfish… Read More
Educational Paul Hui 2023-09-12 Educational Paul Hui 2023-09-12 Beyond structural elucidation, introduction to qNMR – Part I Over the last few years, more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. Read more. Read More