Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Synthetic cannabinoids (SC) are designer drugs that aim to mimic the pharmacological effect of the natural cannabinoid (−)-trans-Δ9-tetrahydrocannabinol (THC). Many SCs have an even higher binding affinity to the CB1 receptor, which is responsible for the psychoactive effects…

As a class of complex cross-linked phenolic macromolecules, lignin is an important component of plant-based biomass.1 Biologically, lignin is a major component of lignocellulose, helping to strengthen cell walls in wood. A by-product of paper production…

…more and more analytical and industrial laboratories have started employing quantitative nuclear magnetic resonance (qNMR) spectroscopy as a tool for content assignment (due to its superb structural elucidation abilities) and quantification of purity in a sample. Read More.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

…let’s look at regular eggs! Specifically, we’re going to look at cholesterol in the egg yolk. This idea hit me as I was taking my daily dose of raw eggs, when I thought, “why not try and analyze this to see what I am putting in my body?”.

Most NMR users know that phase correction is a very important adjustment that needs to be made to a spectrum. Practically speaking, the phase of a signal is related to the amount of signal observed above and below the baseline.

Are you familiar with the apodization tool in Mnova? Apodization (also referred to as Weighting or Windowing) literally translates to ‘cutting off the feet’ from the original Greek. In this case…

BODIPY dyes, which are boron difluoride compounds supported by dipyrrinato ligands, have gained recognition as being one of the more versatile fluorophores due to their superior photophysical properties.[1,2] BODIPY derivatives are used as stable functional dyes in several fields such as light harvesters, laser dyes, fluorescent switches, and biomolecular labels.[3-6] They gained popularity as biological probes due to the easy modification of the ligand framework, extension of the chromophore, and substitution of the fluorine atoms.6 Figure 1 shows some commercially available BODIPY dyes used as biological probes.

While low-field NMR has extremely favourable accessibility and affordable characteristics, the most common question that we get asked about our family of benchtop NMR spectrometers is with respect to any trade-offs that come from moving to lower-field.