What is process analytical technology (PAT) and why is it so important?PAT is an extremely powerful and useful tool for analyzing, optimizing and controlling chemical processes. Chemical, food and pharmaceutical industries could especially benefit from this technique. In earlier days, chemical processes were primarily monitored by physical techniques, such as temperature, pH, pressure etc..

Last month (which you can see here), we learned about how an acidic proton behaves in a 1H NMR experiment, particularly when it’s surrounded by D2O. For example, when an H+ leaves CH3COOH to join an accommodating D2O molecule, the resulting acetate (H3CCOO–) segment is reasonably comfortable bearing that negative charge. This phenomenon is the reason the solution is “acidic” in the first place. But why is acetate so capable of dealing with this negative electronic charge?

Acidity is something that you encounter on a daily basis, probably without even realizing it. The tangy taste of an orange (citric acid), that Vitamin C tablet you took this morning (ascorbic acid), those terrible jeans from the 80’s that you still wear (acid wash). My favourite acid is acetic acid.

Electronegativity is a concept that we have to study and understand early in our science or engineering degrees. In chemistry this concept stays with us and we commonly invoke it in order to explain multiple phenomena what we observe or study…and of course, NMR is not the exception! Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

The compact NMR 60PRO can acquire both, coupled 31P and decoupled 31P NMR spectra. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

2,4-pentanedione (aka acetylacetone, acetylacetonato or acacH) is not only a ubiquitous ligand (AND ligand precursor!) for beautifully coloured organometallic complexes[1-3].. Read more.

In November 2014 Nanalysis was pleased to announce the expansion of their product line with the NMReady-60PRO.  With this we also extended our experiment library for the NMReady-60e

Sustainability has become a main focus of innovation.  Topics of green chemistry, and renewable feedstocks, are paramount in society today.  Biodiesel is one such example!  Read more.

Learning about the parameters that are vital for obtaining good spectra – a concept that I had learned about in a theoretical sense, but as a synthetic chemist rarely thought about when collecting routine data.