Nuclear magnetic resonance (NMR) is a critical tool for scientists undertaking structural elucidation or quantification of species in mixtures. Along with single crystal X-ray diffraction (SCXRD), no other technique provides as much information about a molecule’s conformation as NMR. This approach provides information about molecules in solution. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

It is well known that NMR analysis requires a higher concentration of analyte than any other spectroscopic method. For example, UV-Vis requires an analyte concentration range of only nM to µM, while NMR typically requires the analyte to be in the mM range (>1000 times more concentrated!). In this blog, we will demonstrate why NMR is considerably less sensitive than UV-Vis. We have chosen UV-Vis for this comparison as it is widely recognized as one of the most sensitive spectroscopic techniques.

This year, to bring out that Christmas spirit inside of everyone, I would like to talk about Santa Claus. Now, I know there are a plethora of Christmas treats out there that you will be making, but for the big man flying through the skies, there is one treat that stands head and shoulders above all else. I’m talking, of course, about cookies. However, with the never-ending list of cookies the big question becomes: which one are you making for Santa? With this blog, I might be able to provide you with a little bit of guidance.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

Have you ever been curious as to why your pumpkin spice latte doesn't taste like pumpkins? Pumpkin spice is actually a mix of spices; such as, nutmeg, ginger, cloves, cinnamon, etc. In this blog, we focus our attention on cinnamon, where we obtain the 1H NMR spectrum using benchtop NMR. We then compare this with known molecules that comprise cinnamon such as, cinnamic acid and cinnamaldehyde. Read more.

Chirality has a huge impact on the chemistry of a molecule. Due to potentially different physiological effects, pharmaceutical compounds are often used as enantiomerically pure compounds. One enantiomer can act as a healing agent, the other might be toxic to humans. Crazy, right?

It is well known that signal dispersion decreases as the NMR field strength is reduced. For example, at 400 MHz, 1 ppm spans 400 Hz while at 60 MHz, 1 ppm spans 60 Hz.

NMR users can deal with spectrum evaluation in the daily work, but how is the spectrum information stored in the time domain (FID)? Read more.

Nuclear Magnetic Resonance spectroscopy is based on the idea that some nuclei can behave as little magnetic bars (I spin number ≠ 0). In the presence of a magnetic field (B0) the nuclear spins feel a small torque for or against the B0 axis, which results in a net magnetization along the B0 direction. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada.

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.