Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

NMR is a great tool for the analysis of molecular properties such as the amide bond, which has a restricted rotation around the C–N bond. In Biochemistry, the amide bond is referred to as the peptide bond. This bond is formed by the union of a carboxyl group of one amino acid with the amino group of another amino acid. Read more.

In this blog, we showcase how benchtop NMR is an accessible and versatile tool for chemists and non-chemists to evaluate greener methods.

NMR is a great tool for the analysis of molecular properties such as the amide bond, which has a restricted rotation around the C–N bond. In Biochemistry, the amide bond is referred to as the peptide bond. This bond is formed by the union of a carboxyl group of one amino acid with the amino group of another amino acid. Read more.

Given the superior resolution of our 100 MHz instrument, we can perform structure elucidation on increasingly large molecules. As molecules get more complex, as do the suite of experiments that can be used to…

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…

Chirality has a huge impact on the chemistry of a molecule. Due to potentially different physiological effects, pharmaceutical compounds are often used as enantiomerically pure compounds. One enantiomer can act as a healing agent, the other might be toxic to humans. Crazy, right?

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Tautomers are constitutional isomers that interconvert into each other by an exchange reaction, most commonly a proton transfer. Such two isomers can for example be a ketone and an enol. Keto-enol tautomerism (KET) becomes possible when there are hydrogen atoms adjacent to a carbonyl group (these hydrogen atoms are called α hydrogens). This tautomerism is depicted in Scheme 1 and is also discussed…