Fluorine-19 is one of the most popular nuclides in NMR, along with 1H, 13C and 31P. It has a relatively large chemical shift window (-300 to 400 ppm), which minimizes signal overlap even at low fields, is 100% naturally abundant, and its sensitivity is nearly as high as proton. Read more.

Nuclear Magnetic Resonance spectroscopy is based on the idea that some nuclei can behave as little magnetic bars (I spin number ≠ 0). In the presence of a magnetic field (B0) the nuclear spins feel a small torque for or against the B0 axis, which results in a net magnetization along the B0 direction. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada.

Hello fellow NMR enthusiasts, have you ever wondered what tritium (3H) looks like via NMR? I know I have, and today, I would like to share some data with you. Read noww.

Proton and carbon NMR analyses are routinely used in organic laboratories. In proton, 1H-1H coupling pattern is well exploited, and 1H-13C couplings as referred to as the carbon satellites. However, when acquiring carbon data, proton decoupling is applied most of the time and consequently it is not common to evaluate 1H-13C couplings in routine carbon analysis. This blog discusses the 1H-13C coupling in tert-butanol through 1D and 2D data, highlighting the key info. Read more.

NMR is a great tool for the analysis of molecular properties such as the amide bond, which has a restricted rotation around the C–N bond. In Biochemistry, the amide bond is referred to as the peptide bond. This bond is formed by the union of a carboxyl group of one amino acid with the amino group of another amino acid. Read more.

Given the superior resolution of our 100 MHz instrument, we can perform structure elucidation on increasingly large molecules. As molecules get more complex, as do the suite of experiments that can be used to…

Distortionless Enhancement by Polarization Transfer (DEPT) is a double resonance pulse program that transfers polarization from an excited nucleus to another – most commonly 1H → 13C. This results in a sensitivity enhancement relative to the standard decoupled 1D carbon spectra (13C), which benefits only from the small Nuclear Overhauser Effect (NOE) enhancements.

Have you ever questioned why hydroxyl groups/alcohol signals appear as singlet in the 1H NMR spectrum? Shouldn’t they also couple with neighboring hydrogen atoms and show the corresponding splitting pattern? Yes…no…why? Don’t worry! We’ll get to the bottom of it and discuss how exchange rates, concentrations, and the presence of water affect the NMR spectra of ethanol in CDCl3. Benchtop NMR solves so many questions – feel free to reach out to us to make sure yours can answered too.

Nuclear magnetic resonance (NMR) is a critical tool for scientists undertaking structural elucidation or quantification of species in mixtures. Along with single crystal X-ray diffraction (SCXRD), no other technique provides as much information about a molecule’s conformation as NMR. This approach provides information about molecules in solution. Benchtop NMR 1-855-NMREADY (667-3239) toll-free in the US and Canada

It is well known that NMR analysis requires a higher concentration of analyte than any other spectroscopic method. For example, UV-Vis requires an analyte concentration range of only nM to µM, while NMR typically requires the analyte to be in the mM range (>1000 times more concentrated!). In this blog, we will demonstrate why NMR is considerably less sensitive than UV-Vis. We have chosen UV-Vis for this comparison as it is widely recognized as one of the most sensitive spectroscopic techniques.