Dr. Yuri Falcao, Lab and Operations Coordinator, Velocity Incubator
Velocity is a business incubator, funded by the University of Waterloo, that hosts multiple startup companies and helps them with mentors, advisors, office space, funding, and any other things a new business would need. We host 15 deep-tech startups and in total we have 60 or 70 startups. It’s amazing to see such a concentrated group of startups in one place in all sorts of different industries such as medical groups, biotech, chemistry companies, etc. We have a large range of companies in our lab so it’s pretty amazing.
I worked with NMR back in my previous job, in Brazil, and we had a 100 MHz as well as a 600 MHz spectrometer. They were huge, and it took a lot to operate them. They were old fashioned with lots of maintenance, and they both had such long procedures to make them work so the Nanalysis instrument is definitely so much faster. It works so much better, at least from an operational point of view, it works so easily. For startup companies it’s great because most of the time they are running around and developing a product. Since they are a startup, they have to meet timelines and they need to develop as fast as possible to impress investors. Having an instrument that doesn’t need any laborious preparation, just a simple preparation of the sample and clicking on the ‘GO’ to start the analysis, helps these companies a lot. Two of the companies at Velocity work a lot with the benchtop NMR and they only have good feedback about it. It’s so handy for them.
We have a range of different advisors: business advisors, technology advisors, lab advisors, etc. I do the coordination in the lab, and I instruct all the teams on how to use the instruments, including the benchtop NMR. We have two chemical groups that work with development of organic material. One of them is working with organic and inorganic complexes, and the other group is developing a polymer. The second group has a range of monomers that they need to test to make the best polymer for their application. They eventually apply this polymer in the textile industry, so they need to have that specific characteristic where the polymer needs to have a porosity and be hydrophilic. So, all sorts of different applications and characteristics depend on the monomer meaning that they need to immediately test each monomer that they are developing, and it’s so good to have an NMR that’s easy and accessible for that. The groups that use the benchtop NMR are mainly analyzing organic molecules and trying to check if their reaction actually went to the desired product so they can proceed with the next steps of the reaction or synthesis. If they actually achieve what they want, they verify this through the benchtop NMR. Of course, it’s not a 600 MHz NMR, it won’t give that much detail in its analysis, but they can definitely identify what they want. If they want something more specific, they can send the sample to the university but having the benchtop NMR in place and so fast that it takes about 5 minutes to put the sample in, get the result and say, “Okay today we got a good product, let’s keep the reaction and go to the next step”, or “no, let’s go back and fix it”.
Before benchtop NMR we didn’t have any NMR instruments, so we would send out the samples to the university. They have a 120 MHz and a 600 MHz, if I’m not mistaken. The groups would send out their samples to the University of Waterloo or even to the University of Toronto and this takes a lot of time. You need to send a sample, the courier needs to come pick it up, arrive to the university, send the sample to the department of chemistry and then the sample goes into a line of samples that will be analyzed by the lab technician. It takes a lot of time and there are so many steps just for testing a small sample. So, having the benchtop NMR that’s small, fits in the lab, low maintenance, and has easy operation, makes the biggest time difference. We don’t need the result to be so specific, but we need to get results fast and for startups this is crucial. Fast results are the main thing they need to prove that their product is good until they can go for the next investment round.
The first thing we liked [about the benchtop NMR] is definitely the easy operation. The instrument is so fast and it’s so easy to operate. The interface is a big thing as well. The fact that the instrument is a standalone and doesn’t need a computer. It already has all the features it needs packed into one small package! As well as the fact that it is benchtop and portable so I can carry it anywhere. This was such a huge thing because our lab is so compact, and we have many things in a small area so having an instrument that could fit anywhere helped a lot. I think these were the main features that made us decide. As well as the price point compared to traditional NMR. It’s a huge difference.
Nanalysis has a different approach that most traditional NMR companies don’t have of being user-friendly and I love that because most of us chemists aren’t programmers. We are not problem-solvers for the software point of view, we are problem-solvers for the chemical point of view so it’s easy for us to understand the chemistry and what’s going on. But once the instrument stops working, we need a technician. When I had to do the cleanup of the benchtop NMR, I set up a meeting with one of the Nanalysis technicians and it was so fast. He instructed me on how to clean the instrument, how to operate the instrument, and he said, “flip the instrument all the way to the back”, and I replied, “It’s an NMR, are you sure?”. He said, “Oh do it and take the filter out”, so it’s just so great to have such a close contact with a technician. I also had instruments in Brazil that needed a technician and to talk to one I would have needed to pay for their hotel and flight to come to my city, as well as pay them by the hour so the bill racks up quite a bit. That’s why having a technician readily available with Nanalysis is so nice!
At Velocity, because we have so many companies that use the benchtop NMR, the value is totally worth it. We have so many companies that wouldn’t have these resources and wouldn’t be able to afford having an NMR on their own so having a benchtop NMR on our side definitely helps. It is such an incredible tool, along with many other instruments that we have.
Before I knew about your instrument, I didn’t see anything that is as accessible and easy to operate and is accessible for small companies. Since they don’t have tens of millions, they have perhaps a million or a couple of million that they need to use to pay staff, buy reactants, and maintain the company, so it’s really hard for them to allocate a static investment to an instrument that won’t return profits, at least not in the same way that an employee would return them. So, to have this and be able to help these companies is so great! It’s a tool that’s magical for them because it just works, and it works fast because these companies are very chemistry intensive. They might have helium for example, one of them is developing a screen that changes color with a very complex process where they have so many different areas to develop and each of these organic molecules that would change the color depending on the current status applied. It’s such an intensive chemistry related project and having a benchtop NMR helps a lot. I would say that these are some of the companies that if they outgrow their own space in Velocity, they will definitely be reaching out to Nanalysis to purchase their own instrument or to know more about the benchtop NMR. I think that a lot of startups, when they are in a more mature stage, they will take a great advantage of not relying on a big institution that will take 1 week to give them the result.
I like the easy-to-use interface and I like the fast forward. I would definitely try to implement more analytical tools like other traditional NMR instruments. I’ve seen another traditional NMR that had more of a research mode. I come from research labs, and I know that some of our teams would like to dive deeper into tests and this is why they sometimes send their samples to the university to get more analytical reports. So even though the capacity and procedure of the instrument cannot be compared to a research-grade instrument of 120 MHz or 600 MHz, it would be nice to have the tools to get at least the same approach on the results as I would with other instruments. Other than that, everything is so fine-tuned in the Nanalysis benchtop NMR that I wouldn’t do anything else.