‘The spectra were analyzed according to first order’. Does this sound familiar to you? Most of the supporting information documents out there contain this sentence. You find yourself asking ‘why does nobody care about second order effects?’, then check out this high-order blog entry on the topic.

As I’m sure the readers of this blog know, NMR spectroscopy is used widely across all branches of chemistry due to its powerful structure elucidation capabilities and the inherently quantitative nature of the technique. Organic relies primarily on 1H/13C experiments where as inorganic chemistry can expand to other nuclei, like 31P and 11B. However, there are many other applications for NMR other than just structural elucidation. Perhaps a lesser known application of NMR spectroscopy, is its ability to determine the isotopic ratio of elements! In this blog post I would like to demonstrate a novel method to determine the 10B/11B isotopic ratio using our NMReady-60e and 1H NMR spectra!

Are you familiar with the apodization tool in Mnova? Apodization (also referred to as Weighting or Windowing) literally translates to ‘cutting off the feet’ from the original Greek. In this case…

BODIPY dyes, which are boron difluoride compounds supported by dipyrrinato ligands, have gained recognition as being one of the more versatile fluorophores due to their superior photophysical properties.[1,2] BODIPY derivatives are used as stable functional dyes in several fields such as light harvesters, laser dyes, fluorescent switches, and biomolecular labels.[3-6] They gained popularity as biological probes due to the easy modification of the ligand framework, extension of the chromophore, and substitution of the fluorine atoms.6 Figure 1 shows some commercially available BODIPY dyes used as biological probes.